
EN4 MYC inhibitor
CAS No. 1197824-15-9
EN4 MYC inhibitor ( EN4 )
产品货号. M23368 CAS No. 1197824-15-9
EN4 MYC 抑制剂是一种共价配体,靶向 MYC 的半胱氨酸 171 (C171)。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥583 | 有现货 |
![]() ![]() |
10MG | ¥721 | 有现货 |
![]() ![]() |
25MG | ¥1596 | 有现货 |
![]() ![]() |
50MG | ¥2406 | 有现货 |
![]() ![]() |
100MG | ¥3621 | 有现货 |
![]() ![]() |
200MG | 获取报价 | 有现货 |
![]() ![]() |
500MG | 获取报价 | 有现货 |
![]() ![]() |
1G | 获取报价 | 有现货 |
![]() ![]() |
生物学信息
-
产品名称EN4 MYC inhibitor
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述EN4 MYC 抑制剂是一种共价配体,靶向 MYC 的半胱氨酸 171 (C171)。
-
产品描述EN4 MYC inhibitor is a covalent ligand that targets cysteine 171 (C171) of MYC. It is selective for c-MYC over N-MYC and L-MYC, and inhibits MYC transcriptional activity, downregulates MYC targets, and impairs tumorigenesis.
-
体外实验Cell Proliferation Assay Cell Line:231MFP breast cancer cells Concentration:1 μM, 10 μM, 50 μM Incubation Time:72 hours Result:Significantly impaired 231MFP breast cancer cell proliferation in a dose-dependent manner.Western Blot Analysis Cell Line:231MFP breast cancer cells Concentration:50 μM Incubation Time:60 hours Result:The protein levels of CDK2 and CDC25A were significantly lowered.
-
体内实验Animal Model:SCID mice injected with 231MFP breast cancer cells.Dosage:50 mg/kg Administration:Intraperitoneal injection; daily; for 3 weeks Result:Significantly attenuated tumor growth in vivo.
-
同义词EN4
-
通路Cell Cycle/DNA Damage
-
靶点c-Myc
-
受体MYC
-
研究领域——
-
适应症——
化学信息
-
CAS Number1197824-15-9
-
分子量416.47
-
分子式C25H24N2O4
-
纯度>98% (HPLC)
-
溶解度DMSO:250 mg/mL (600.28 mM; Need ultrasonic)
-
SMILESCCOC1=CC=C(C=C1)OC2=CC=CC=C2NC(=O)C3=CC=C(C=C3)CNC(=O)C=C
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Lydia Boike, et al. Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC. Cell Chem Biol. 2021 Jan 21;28(1):4-13.e17.